Occupational Exposure to Organochlorine Pesticides

The study on insecticide hexachlorocyclo-hexane (HCH) was of its own kind that covered all the four HCH manufacturing units in the country. Beta HCH was found to be a predominant isomer present in the blood samples of exposed workers.  This is due to accumulation of Beta-HCH  which is a stable isomer, has a long half-life  and is almost non-biodegradable.  Beta-HCH was found even in the serum samples of workers who had  discontinued their  jobs for several years.  Therefore Beta-HCH is taken as the marker for cumulative exposure for HCH and lindane for immediate past exposure.

 About 25% of serum samples of workers with significantly high levels of serum HCH residues showed circulating immune complexes(CIC) of IgG and 20% showed CIC of IgM whereas CIC of C3 and C4 were not detected. Electro cardiogram abnormalities such as Left Ventricular Hypertrophy (LVH), Left Anterior Hemiblock, Right Bundle Branch Block and Wolff Parkinson White Syndrome were reported for the first time. Increased activity of Lucine amino peptidase. 5-nucleotidase, and Gamma Glutamyl transpeptidase, Ornithine Carbamoyl Transpeptidase was also observed.

Asbestosis
Byssinosis
Pneumoconiosis and Other Respiratory Morbidities Among Coal Miners In India
Noise Pollution and Health Effects
Occupational Exposure to Heavy Metals
Occupational Exposure to Organochlorine Pesticides
Agricultural Ergonomics
Women in Industry: Health and safety

 

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