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Methomyl,
a carbamate insecticide, was introduced in India in 1988-89
for the control of boll worm pest on cotton. Soon after the
introduction, there were some alleged cases of death due to
insecticide exposure amongst spray operators in Andhra Pradesh.
NIOH carried out a systematic study on the toxicity of
methomyl on spray operators. It was observed that in spray
operators with normal pre-exposure ECG, significant T-wave
changes, including inversion, in most of the chest and limb
leads, occurred following 5 days exposure to methomyl. The ECG
changes observed in spray operators could be reproduced in
rabbits in dose dependent manner.
This
was the first report of the cardiac toxicity of methomyl in
human beings and experimental animals. On the basis of the
study results, the registration of Methomyl was cancelled by
the Pesticide Registration Committee and large number of
farmers were saved from the danger of exposure to this highly
toxic compound.
Cardiac Toxicity in Pesticide Formulators exposed to
Organo-phosphate
Insecticides
Non-occupational Pneumoconiosis in high altitude villages of
Ladakh
Byssinosis in Jute Mill Workers
Resolving Fluorosis Controversy in the neighborhood of an
Aluminum Smelter
Identification
of Carcinogen-DNA Adducts in Benzidine Exposed Workers
A New Multi-Method
Ergonomics Review Technique (MMRT) for Work Analysis in
Industry
Determination of Heat Transfer Coefficients for Application of
Human Heat Stress Assessment
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