Subjects

Details

Name of the Department

  Poison Information Centre

Objectives

1.  To reduce morbidity and mortality from toxic exposures.

2.   To prevent poisoning through toxicovigilance

Functions of the Department

Established in the year 1993 with technical collaboration of IPCS/WHO, the Poison Information Centre provides toxicological information and consultation in acute poisoning other activities of the centre includes :

1.    Laboratory support in the acute poisoning cases

2.     Research

3.     Teaching and training

4.      Publication of information cards

5.      Toxicovigilance

Details of Scientific and Technical Staff

Laboratory facilities and Instruments

1.Besides the basic laboratory equipments like analytical balance, chemistry analyzer, deep freeze, etc., the laboratory also possesses  the laboratory equipments like  HPTLC, Desaga, Germany;

   UV-Visible spectrophotometer, Cary-100, Varian, Australia; Spectrofluorimeter SL-174, ELICO

   Table Top cold centrifuge, Hettich 32 R, Germany; ELISA Reader & Washer Awareness USA.

Ongoing Projects

1. Pesticides poisoning database

2.'Occupational and environmental health hazards due to mercury in chloral kali plant'

3.'Health status assessment of the workers employed in due stuff industries'

4. 'Pesticide exposure amongst Formulators and health effects'

5. ' An environmental cum epidemiological study on chromium exposure and its health effects'

Important Projects Completed

 1. Cholinesterase and paraoxonase patterns in organophosphate (OP) poisoning.

2.  Pesticide exposure in farm workers- Phase I- chili cultivators of Gujarat.

3.  Investigation of mass poisoning due to endosulfan at Jabalpur

4.  Environmental epidemiological study related to aerial spray on Endosulfan on cashew nut plantation in Kasargod District of North Kerala.

International Programme (If any)

Hazardous Substances Emergency Events Surveillance (HSEES) - Indo- US collaboration.

Publication and Research Reports:

1. “Experimental studies on manganese toxicity: Neurochemical studies” Sarma TJ and PATEL AB Biol. Memoirs 11, 82-87 (1985)

    2.    “Effect of trace metals on total sialic acids and perchloric acid-soluble proteins and sialic acids in mice. PATEL A.B. and Bhatt HVK,

J Appl Toxicol. 9, 67-68 (1989).

3. “Effect of lead on serum sialic acids and proteins resistant to perchloric acid in rats” PATEL A.B. and Bhatt HVK, Bull.

Environ. Contam. Toxicol. 48(4) 520-22 (1992).

4. “Effect of lead on the blood-serum, liver and brain sialoglycoconjugate levels in rats”  PATEL A B and Bhatt HVK.

Hum. Expt. Toxicol. 11(2), 89-92 (1992).

5. “Dose response effects of cadmium on serum sialic acid alpha-1-acid glycoprotein and perchloric acid- soluble protein levels in rats”.

PATEL A B and Bhatt HVK.

Industrial Health 30, 97-101 (1992).

6. “Sialoglycoconjugate levels in blood-serum, liver and brain of rats intoxicated with cadmium”. PATEL A B and Bhatt HVK.

Rev. Roum. Biochem. 29(1), 35-38 (1992).

7. “Dose related increase in the serum levels of protein-bound hexose after acute exposure with cadmium in rats”.PATEL A B and Bhatt HVK.

Ind. Jr. Pharmacol. 25, 103-104 (1993).

8. “Effect of organic and inorganic mercury on serum total and perchloric acid-soluble sialic acids in rats”. PATEL A B and Bhatt HVK.

Ind. Jr. Physiol. Pharmacol. 37, 259-260 (1993).

9. “Effect of chronic manganese toxicity on tissue levels and urinary excretion of nicotinamide nucleotides in rats”. PATEL A B and Pandya A A

Hum. Expt. Toxicol. 13, 307-309 (1994).

10. “Rasayano Sameh Khataro Tatha Salamati na Upayo”.

Parikh J R, Gokani V N, PATEL A B, Doctor P B, Gandhi D N and Saiyed H N (1998).

11. “Sialic acids: Current status and future” PATEL A B and Bhatt HVK,

Proc. Acad. Environ. Biol. 8(2), 267-279 (1999).

12. “Manganese toxicity and its influence on antioxidant enzymes ”

PATEL A B, Gandhi D N and Bhatt HVK.

Proc Acad Environ Biol. 9(2), 147-151 (2000).

13. “Acute Methoglobinemia-a common Occupational Hazards in an industrial city in Western India”  Aruna    Dewan, Ashwin Patel and Habibullah Saiyhed.

Jr. of Occup. Hlth. 43, 168-171 (2001).

  14.     “Early biochemical alterations in Manganese toxicity: Ameliorating     effects of Magnesium nitrate and Vitamins”

Zaidi Shakeel, Ashwin PATEL, Nilesh MEHTA, Kanaiyalal PATEL, Ramnath TAKIAR and Habibullah SAIYED.

Industrial Health 43, 663-668 (2005).

  15.     “Distribution Profile of Paraoxonase Phenotypes among the Gujaratis”.

Patel A. B., Pal R., and Dewan A.

Ind J Hum Genet 13, 65-68 (2007).

  16.     “Mass Organophosphate pesticide Poisoning with High Mortality”.

Aruna Dewan,  Ashwin B Patel,  Ramavati R Pal, Umesh J Jani, Vinu C Singel, Maulik D Panchal

Clin Toxicol 46, 85-88 (2008).

Future Programmes

 Research on dose of oximes for different OPs.

Miscellaneous information  

-Nil